Among the patients with PRL (SCr >1.5 mg/dL), 21.1% (15 out of 71 patients) developed CIN in 48/72 hours, whereas among the patients without PRL, only 13.7% (101 out of 733 patients) developed CIN (p < 0.001). The gene discussed is PRL; the disease is cervical squamous intraepithelial neoplasia.