Even the randomized study PRavastatin Inflammation CRP Evaluation (PRINCE) [14] showed that in 80% of patients with CIN, serum creatinine starts to increase in the first 24 hours after being exposed to contrast medium and almost all patients who progress to serious renal failure (requiring nephrology consultation or dialysis) have an increase in serum creatinine during the first 24 hours. This evidence concerns the gene CRP and cervical squamous intraepithelial neoplasia.