In our research, we observed that 1) the incidence of CIN resulted in 14.%; 2) PRL, age ≥65 years, and HF resulted in independent RFs for CIN, whereas anemia, DM, and volume contrast did not; 3) HF resulted as the most important RF for high-risk CIN; and 4) CIN in 24 hours resulted predictive of CIN in 48/72 hours. This evidence concerns the gene PRL and hydrops fetalis.