ARID5B encodes a DNA-binding protein with roles in NK cell function (Cichocki et al., 2018), cancers of both B and T lymphocytes (Healy et al., 2010; Zeng et al., 2014; Leong et al., 2017), and autoimmune disease (Wang et al., 2012; Yang et al., 2013). Here, ARID5B is linked to autoimmune disease.