Analysis of the effects of MTHFR C677T and A1298C polymorphic variants on rectal cancer risk using codominant, dominant, recessive and overdominant models was represented using p value < 0.05; odds ratio (OR) and 95% confidence interval which are shown in Table 3, using a previously published method (Ozretić et al., 2019). Here, MTHFR is linked to rectal cancer.