MTHFR and rectal cancer: The aim of this study was to examine the association of MTHFR C677T and A1298C single nucleotide polymorphisms with the risk of rectal cancer as well as the response to neoadjuvant chemoradiotherapy based on 5-Fluorouracil (5-FU)/leucovorin (LV) in the locally advanced setting, in an effort to provide data from the Western Balkan area which is usually underrepresented in larger meta-analyses.