TNF and ankylosing spondylitis: Sieper and Braun jointly published an article entitled “Ankylosing spondylitis” in the Lancet in 2007 (3); systematically describing the pathogenesis and treatment of AS and pointing out that while tumor necrosis factor blockers are good news for refractory patients, nonsteroidal anti-inflammatory drug therapy and physical therapy remain the preferential long-term treatment options for conventional AS patients.