TGFB1 and neoplasm: The nanopolymer also reprograms the tumor immune microenvironment by reducing PD-L1, IDO-1, and TGF-β and increasing CD8+ T cells, M1-like macrophages, which unleashes the potential of transforming the tumor from cold tumor to hot tumor, greatly inhibiting tumor growth, and improving the survival rate of bladder cancer mice (119).