The interaction between other cells in the glomerulus and podocytes is critical in the development of glomerular diseases.Research has demonstrated a correlation between mitochondrial oxidative stress in glomerular endothelial cells and an increased expression of Endothelin-1 (Edn1) along with its receptor, Endothelin-1 receptor A (Ednra) (46). The gene discussed is EDN1; the disease is glomerular disorder.