Notably, the preferential expression of TCR Vβ gene expression in intrarenal T cells, driven by antigen stimulation compared to peripheral blood lymphocytes, and the high expression of IL-4 and IL-10 on intrarenal T cells from LN patients, suggest that intrarenal T cells potentially play a critical role in the pathogenesis of LN (130). This evidence concerns the gene IL10 and lobular neoplasia.