The TIMER results exhibited that C4ORF19 had a significant positive correlation with CD274 (r = 0.361; p = 1.21e−15) and HAVCR2 (r = 0.137; p = 3.15e−03) and a significant negative correlation with PDCD1 (r = −0.129; p = 5.46e−03) and CTLA4 (r = −0.095; p = 4.11e−02; Figure 18I), suggesting that C4ORF19 may play a vital role in the ICB treatment of ccRCC. The gene discussed is CTLA4; the disease is nonpapillary renal cell carcinoma.