It has been reported that the deubiquitinating enzyme family OTUD3 can directly interact with the tumor suppressor protein PTEN and stabilize PTEN through deubiquitination modification, thereby antagonizing the PI3K-AKT signaling pathway and exerting a tumor suppressor function (Yuan et al., 2015; ZhEl-Kott et al., 2020). This evidence concerns the gene AKT1 and neoplasm.