Through the analysis of the GEPIA2 database and the expression level differences of OTUD3 in various tumors and corresponding control tissues from The Cancer Genome Atlas (TCGA), we observed a significant downregulation of OTUD3 in multiple tumors such as Ovarian Serous Cystadenocarcinoma (OV), Testicular Germ Cell Tumors (TGCT), Uterine Corpus Endometrial Carcinoma (UCEC), and Uterine Carcinosarcoma (UCS). The gene discussed is OTUD3; the disease is ovarian serous cystadenocarcinoma.