The source of this residual CV risk is multifactorial and includes lipid and nonlipid factors (32), such as smoking, obesity, DM, elevated TG levels or low high-density lipoprotein cholesterol, non–high-density lipoprotein cholesterol, apolipoprotein B levels, lipoprotein (a) [Lp(a)], and LDL particle numbers (32, 55). The gene discussed is APOB; the disease is diabetes mellitus.