Exploratory analysis of the Japan Statin Treatment Against Recurrent Stroke study, which initially evaluated the effect of pravastatin 10 mg on stroke recurrence in 1,095 patients with ischemic stroke, investigated the effect of on-treatment LDL-C and C-reactive protein levels on the risk of recurrent stroke and transient ischemic attack in patients with history of ischemic stroke (46). The gene discussed is CRP; the disease is ischemic stroke.