Our screening test detects the 10 ERBB2 mutations most frequently observed in breast cancer (p.S310F, p.S310Y, p.L755S, p.D769H, p.D769Y, p.G776V, p.V777L (G>C), p.V777L (G>T), p.V777M, and p.L869R) according to the Catalog of Somatic Mutations in Cancer (COSMIC) database. The gene discussed is ERBB2; the disease is cancer.