CCL2 and chronic kidney disease: For instance, upongeneticinductionofchronicKIM-1expression in the absence of any injury in mice, extensive interstitial fibrosis, monocyte chemotactic protein-1 (MCP-1) upregulation, and MCP-1-dependent macrophages chemotaxis were prominent along with the emergence of a chronic kidney disease (CKD) phenotype by 4 weeks of age [86].