Kato et al. [101] demonstrated the underlying effect of CD147 and E-selectin interaction as an inducer of renal inflammation in ischemia/reperfusion; thus, demonstrating that neutrophil migration, a key contributor in AKI, resulting from E-selectin binding to CD147, was suppressed in CD147-deficient mice, resulting in a decreased tubular injury. Here, SELE is linked to acute kidney injury.