It has also been reported that the activation of TLR4 on platelets following SARS-CoV-2 infection may explain the observed thrombotic events in COVID-19 patients, such as myocardial infarction, which potentially leads to kidney damage through the cardio–renal interrelationship, otherwise known as cardio–renal syndrome [20,66]. Here, TLR4 is linked to COVID-19.