Furthermore, by analyzing the Chinese Glioma Genome Atlas (CGGA)29 and TCGA glioma transcriptome sequencing data, we found a positive correlation between PVT1 expression levels and the 2016 WHO molecular grading of glioma, which increased with the rising pathological malignancy of glioma tissues (Figure 1C,D, and Figure S1A,B). Here, PVT1 is linked to central nervous system cancer.