Elevated concentrations of HDL, IL-2, TG, aPL-IgM, Anti-β2GPI-IgA, and Anti-β2GPI-IgM were positively associated with the presence of hyperlipidemia in stroke patients (P = 0.022, χ2 = 5.895; IL-2: P = 0.029, χ2 = 5.597; TG: P < 0.001, χ2 = 28.928; aPL-IgM: P = 0.003, χ2 = 8.565; Anti-β2GPI-IgA: P = 0.040, χ2 = 4.607; Anti -β2GPI-IgM: P = 0.002, χ2 = 9.852). Here, CD40LG is linked to hyperlipidemia.