Conversely, decreased concentrations of IL-4, IL-6, IL-10, TNF-α, and INF-γ were negatively correlated with stroke patients suffering from multiple risk factors (IL-4: P < 0.001, χ2 = 49.153; IL-6: P < 0.001, χ2 = 50.059; IL-10: P < 0.001, χ2 = 32.126; TNF-α: P < 0.001, χ2 = 51.946; INF-γ: P < 0.001, χ2 = 50.909) (Fig. 2F). The gene discussed is TNF; the disease is stroke disorder.