Lower concentrations of IL-4, IL-6, and TNF-α were negatively correlated with stroke patients suffering from hyperhomocysteinemia (IL-4: P = 0.015, χ2 = 6.040; IL-6: P = 0.015, χ2 = 6.038; TNF-α: P = 0.016, χ2 = 6.243) (Fig. 2E). Here, TNF is linked to hyperhomocysteinemia.