Group C differed significantly from the other groups with regard to basal levels of FSH, LH, oestradiol and AMH; this was doubtless related to the higher prevalence of polycystic ovary syndrome (PCOS) in group C. The proportion of women with Fallopian tube defects was significantly higher in group D than in the other groups. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.