ADAMTS18 and breast cancer: In addition, the mammary tumor-bearing Her2t/w/Adamts18−/− mice exhibited significant lung metastases when compared with Her2t/w/Adamts18+/+ mice (-/- vs. + / + : 9 of 32, ~ 28% vs. 0 of 36, 0%; P = 0.0022) (Fig. 2C and D).