ADAMTS18 and neoplasm: The median survival time of Her2t/w/Adamts18−/− mice was shorter than that of Her2t/w/Adamts18+/+ mice (26 months vs 28.8 months, P = 0.0001) (Additional file 1: Fig. S1C), but the survival curve does not distinguish between natural and tumor-related deaths as mice both with and without visible tumors began to die after 26 months.