The following search terms were applied: ‘‘PBC’’ or ‘‘primary biliary cholangitis’’ or ‘‘primary biliary cirrhosis’’ or ‘‘UDCA’’ or ‘‘Ursodeoxycholic Acid’’ or “bezafibrate’’ or ‘‘fenofibrate’’ or “budesonide” or “seladelpar’’ or “MBX-8025’’ or “elafibranor’’ or “saroglitazar’’ or “peroxisome proliferator-activated receptor” or “PPARs’’ or “OCA’’ or “obeticholic acid’’ or “FXR” or “farnesoid X receptor agonist” or “aldafermin’’ or “NGM282’’ or “FGF19’’. The gene discussed is FGF19; the disease is primary biliary cholangitis.