In the multivariable Cox PH models, adjusting for tumour size, lymph node, ER, and HER2 status, the predGrade3 remained associated with a higher risk of death/recurrence (HR = 2.27, 95%CI = 1.07–4.82, p-value = 0.033) (Fig. 5d). This evidence concerns the gene ERBB2 and neoplasm.