Expressions of inflammatory cytokine (IFNγ) and T lymphocyte activation (CD25) were also examined in the tumor-infiltrating CD8 T cells, and were significantly increased in mice receiving ACT of CD44high CD8 T cells from the FLT3L-treated OT-1 mice (Fig. 3E, F, Additional file 1: Figure S11). The gene discussed is FLT3LG; the disease is neoplasm.