Through LASSO analysis, we identified 13 macrophage-associated genes that are significantly correlated with GC clinical outcomes, including CPNE8, AKR1B1, MARCKS, ANXA5, SERPINE1, GAMT, SNCG, MATN3, SLC7A2, CYTL1, LIN7A, GJA1, APOD. Here, GJA1 is linked to gastric cancer.