These include carcinoembryonic antigen (CEA) [26], tumor size [26], standardized uptake value maximum (SUVmax) [27], female [28], never smoker[28], adenocarcinoma histology [28], positive N1 lymph nodes on positron emission tomography (PET) [29], blood inflammation biomarkers [30], neutrophil to lymphocyte ratio (NLR) [31] and consolidation-to-tumor ratio (CTR) [32], ect. This evidence concerns the gene CEACAM5 and adenocarcinoma.