Intriguingly, in our study, we observed that TIR treatment prevented the HG induced mRNA and protein downregulation of GLUT3 along with GLUT1, GLUT4, and SORBS1, a protein that takes part in diabetes pathogenesis [31], and regulates GLUT4 translocation [32] affecting neuronal insulin resistance [63]. This evidence concerns the gene SLC2A4 and diabetes mellitus.