Our results firstly demonstrated that 7 days of TIR treatment significantly activated the CREB/BDNF signaling cascade and the associated downstream pathways in neuroblastoma cell line (SHSY5Y) exposed to normal (NG) and high glucose (HG) concentration thus suggesting potential implications of TIR in term of neuroprotection and neurodegenerative disorders prevention. Here, CREB1 is linked to neuroblastoma.