Furthermore, Klotho protein levels displayed significant associations with WBC count, NLR, eosinophil (Eos) count, albumin, ALT, AST, BUN, lactate dehydrogenase (LDH), creatinine, history of alcohol consumption, history of heart failure, history of myocardial infarction and history of diabetes (P < 0.05 for all). This evidence concerns the gene KL and heart failure.