Analysis of oncogenic signature gene sets, a set of genes characterizing cellular pathways commonly misregulated in cancer, revealed that dysregulated cellular pathways in GBM included KRAS.600 UP.V1 DN, KRAS.600 UP.V1 UP, STK33 SKM UP, STK33 NOMO UP and STK33 SKM DN (Fig. 3G). The gene discussed is STK33; the disease is glioblastoma.