TBK1 and amyotrophic lateral sclerosis: Gene mutations in both OPTN and TBK1 have been found in patients suffering from amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), suggesting physiological and molecular links between OPTN and TBK1 (Cirulli et al, 2015; Evans and Holzbaur, 2019).