ASPG and allergic disease: Both conditions are associated with inactivation of asparaginase enzyme activity (AEA) and switching treatment to another asparaginase formulation is indicated [7, 11, 12] Additional allergy-like reactions is a type of asparaginase hypersensitivity with more varying symptoms mimicking true allergies, but - importantly - the AEA is unaffected and peg-asparaginase treatment may proceed if the symptoms are not too pronounced [3, 13].