In addition, a decreased frequency of tumor-infiltrating effector memory cells (CD44+CD62L−) was observed among adoptive CD45.2+ OT-I CD8+ T cells from Id2fl/flCd4-Cre+ OT-I mice compared to Id2fl/flCd4-Cre− OT-I mice (Fig. 5B). This evidence concerns the gene CD8A and neoplasm.