Notably, ccRCC tissues showed limited or almost no presence of BEX2 + renal tubule cells, PTHLH + renal tubule cells, SFRP2+ renal tubule cells, KLRB+ renal tubule cells, and HGF + renal tubule cells (Supplementary Fig. 3). Here, PTHLH is linked to nonpapillary renal cell carcinoma.