There were strong expression of BDNF, TrkB, and p75NGFR in perineural tumor cells of human cutaneous squamous cell carcinoma17, and over-expression of TrkB results in altered expression of molecular mediators of EMT, including downregulation of E-cadherin and upregulation of Twist in HNSCC18. The gene discussed is BDNF; the disease is neoplasm.