Given that expression of TCF7 and Teff score were significantly elevated in the high SLAMF6 group than in the low SLAMF6 group, it is conceivable that there might be a correlation of cDC1 and progenitor-exhausted T cells expressing SLAMF6. Of note, these prior results were obtained from preclinical model or melanoma patients18,29,31. The gene discussed is TCF7; the disease is melanoma.