Several specific examples of the consequences of hypoxic signaling include: increased angiogenesis via enhanced vascular endothelial growth factor (VEGF) secretion6, promotion of an immunosuppressive microenvironment by reprogramming of tumor-associated macrophages7, increased activation of myeloid-derived suppressor cells8, and inhibition of T-cell mediated ant-tumor immunity9,10. Here, VEGFA is linked to neoplasm.