Notably, injured PT DARs were significantly enriched for NF1, HNF1B, and FOS motifs (NF1 P = 1.0 × 10−266; HNF1B P = 1.0 × 10−214; FOS P = 1.0 × 10−204), known regulators of PT identity, suggesting that epigenetic regulation may have implications for the development of kidney disease. The gene discussed is FOS; the disease is kidney disorder.