We demonstrate that the cluster-enhanced nanoporesensor can detect and differentiate the only two cysteine-containingpeptides originating from leucine-rich α-2 glycoprotein 1 (LRG-1)protein biomarkers that have been shown to be present in the urineof ovarian cancer patients.30 This is importantbecause LRG-1 is becoming a highly sought after target for diseasemonitoring,33 and this technique couldbe used as a detector. Here, LRG1 is linked to ovarian cancer.