To establish whether E-cadherin+ CD8+ T cells could form conventional β-catenin interactions with BEC in these livers, we assessed the distribution of β-catenin expression in PBC liver in relation to E-cadherin and CD103+ CD8+ T cells using multiplex IHC (Fig. 7b; Supplementary Movie 5). This evidence concerns the gene CD8A and primary biliary cholangitis.