To explore whether NPM1 might regulate the expression of ECM-related genes, we knocked down NPM1 and measured the expression of ECM-related genes in GBM cells by qRT-PCR and WB assays, which showed that expressions of FN1, COL4A1, and LUM were significantly reduced in NPM1 KD cells (Fig. 3H–K). Here, FN1 is linked to glioblastoma.