RUNX1 and neoplasm: Subsequently, we performed Masson’s staining to evaluate the ECM status in GBM tumors, which indicated the presence of a border band (white line) between borders of low levels of Runx1 expressing tumors, whereas the border band at the tumor-normal tissue junction disappeared in Runx1 OE tumors, implying that the ECM remodeling might be induced by Runx1 in GBM tumors (Fig. 6N, O).