While Se metabolites like methylselenol have been suggested to be important mediating species in cancer prevention and treatment [5, 9, 13], the role of selenoproteins like selenoprotein P (SELENOP) has been increasingly acknowledged, not only in the context of cancer but also in other critical diseases such as diabetes and Alzheimer’s disease [1]. The gene discussed is SELENOP; the disease is early-onset autosomal dominant Alzheimer disease.