Subclustering and GSEA in non-malignant cell clusters revealed similar tumor-wide changes in transcriptional phenotype, with increased IFNα, IFNγ, inflammatory response and IL2-Stat5 signaling again observed (Fig. 3h–k and Extended Data Fig. 4d–k) as well as decreases in oxidative phosphorylation (Fig. 3l and Extended Data Fig. 4l). This evidence concerns the gene IL2 and neoplasm.