IFNG and neoplasm: These consistent markers of altered tumor metabolism were coupled to divergent transcriptional signatures between control and mutant tumors (Fig. 3c), with several indicators of altered immune signaling being significantly elevated in mutant tumors compared with controls; notably, allograft rejection, interferon-γ (IFNγ) and interferon-α (IFNα) responses and IL-mediated cytokine signaling gene sets.