These indicators of a broad anti-tumor immune response were further supported by decreases in immunosuppressive tumor-resident S100a9+ neutrophils, Hmox1+ macrophages15 and Chil3+ monocytes16 as well as increases in pro-inflammatory Birc5+ (ref. 17) and CD74+ (ref. 18) macrophage populations (Fig. 3m and Extended Data Fig. 4m,n). This evidence concerns the gene CD74 and neoplasm.