DNM1L and obesity due to melanocortin 4 receptor deficiency: In human subcutaneous WAT, DNM1L (encoding human Drp1 protein) expression was positively correlated with body mass index (BMI) and HOMA-IR (Fig. 5h,i) and its expression was significantly upregulated in obese individuals (Fig. 5j), indicating that increased expression of DNM1L may contribute to mitochondrial dysfunction in obesity.