RNA sequencing (RNA-seq) analysis from isolated mature adipocytes derived from control and HFD-fed mice28 revealed that Rala expression is significantly upregulated in adipocytes from epididymal WAT (eWAT) and iWAT during obesity development, whereas Ralgapa2 expression is downregulated (Fig. 1a,b). The gene discussed is RALGAPA2; the disease is obesity disorder.