Insulin levels and homeostasis model assessment of insulin resistance (HOMA-IR) in RalaAKO mice were not different from control mice fed with CD (Extended Data Fig. 2g,h); however, RalaAKO mice gained significantly less weight than control littermates when challenged with 60% HFD (Fig. 1e), including a marked reduction of fat mass, with no change in lean body mass (Fig. 1f). The gene discussed is INS; the disease is Insulin resistance.