Mechanistically, the results of western blotting suggested that reticuline inhibited the HDM‐induced upregulation in the phosphorylated levels of JAK2 and STAT3 and the levels of SOCS3 in both LFD and HFD groups (Figure 5A–D), suggesting that reticuline blocked the JAK2/STAT3/SOCS3 signaling in obesity‐related asthma mice. This evidence concerns the gene SOCS3 and obesity due to melanocortin 4 receptor deficiency.