Additionally, we further demonstrated the inhibitory effects of reticuline on the JAK2/STAT3/SOCS3 and p38 MAPK/NF‐κB signaling pathways in the HFD and OVA‐induced obesity‐related asthma models (Figure S2A–G). The gene discussed is STAT3; the disease is obesity due to melanocortin 4 receptor deficiency.