H2AX and cancer: On the other hand, phosphorylated H2AX (γ‐H2AX) might act as a platform to recruit components of the repair machinery such as BRCA1 to DSB foci to promote DSB repair.[31] BRCA1 and γ‐H2AX form a physical complex to facilitate HR repair.[32] The impaired interactions of BRCA1 with γ‐H2AX, which increase DSB levels, are associated with a variety of major diseases, such as cardiovascular diseases,[33] ovarian aging,[34] and cancers.[35] However, it is still unclear whether and how BRCA1 might be recruited by γ‐H2AX to promote HR repair in human trophoblast cells.