Oxidative stress is tightly linked to pro‐inflammatory cytokines, such as TGFβ, IL‐6, and EGF.[12, 13] For example, TGFβ can directly induce ROS production in mitochondria.[14] To ascertain the repressive effect of ROS on ECAD expression, we treated HCC cells with recombinant TGFβ1, IL‐6, and EGF proteins. This evidence concerns the gene TGFB1 and hepatocellular carcinoma.