When ECAD is downregulated, β‐catenin can translocate into the nucleus thereby activating Wnt target genes.[27] Wnt signaling is an important stemness‐related pathway that contributes to the formation of cancer stem cells (CSCs).[28] CSCs have powerful antioxidant capacity conferring survival under oxidative stress, which facilitates tumor metastasis.[29] Therefore, based on our findings and published literature, we speculated that the interplay between RNF25, ECAD, and β‐catenin promotes tumor dissemination in different metastatic stages. Here, RNF25 is linked to cancer.