In breast cancer, HMGB1 and TNF‐α have been found to promote macrophage recruitment and M1 polarization, leading to a systemic anti‐tumor abscopal response triggered by RT.[11] Additionally, hepatic CD169+ macrophages have been identified as a key factor responsible for the RT‐induced abscopal effect.[12] Macrophages can be classified into two main phenotypes: M1 and M2. This evidence concerns the gene TNF and neoplasm.