In this study, it is elucidated that RT can induce the abscopal effect in melanoma by utilizing tumor‐derived exosomes to activate the circPIK3R3/miR‐872‐3p/IRF7 pathway in macrophages, which stimulates the IFN secretion, enhancing the anti‐tumor immune response of CD8+ T cells. The gene discussed is IRF7; the disease is melanoma.