TNF and neoplasm: In earlier studies, our research team discovered that after RT, tumor cells undergo necrosis, leading to the release of dsDNA and inducing the production of IFN‐β and TNF‐α in macrophages via the cGAS/STING axis, resulting in the positive feedback between iRhom2 and TNF‐α.[27] RT‐induced macrophage polarization is regulated by factors such as radiation dosage and fractionation scheme.