demonstrated that RT‐MPs (RT‐microparticles) polarize microenvironmental M2 tumor‐associated macrophages (M2‐TAMs) to M1‐TAMs and modulate anti‐tumor interactions between TAMs and tumor cells.[31] We found that melanoma‐derived exosomes induced M1 polarization of macrophages via IRF7 upregulation after RT. This evidence concerns the gene IRF7 and melanoma.