CXCL12 and melanoma: It is stable, resistant to degradation, and involved in diverse biological regulation within the TME, including immune surveillance, angiogenesis, extracellular matrix remodeling, and resistance to radiation and chemotherapy.[32] Our previous study on melanoma showed that circ_0020710 acts as a sponge for miR‐370‐3p, leading to increased CXCL12 expression.[33] This in turn reduces the infiltration of CD8+ T cells and induces the formation of an immunosuppressive microenvironment.