Notably, it has been established that IRF7 can upregulate the co‐stimulatory molecule CD80 and promote the secretion of pro‐inflammatory cytokines such as IL‐12 and IL‐15 in macrophages, thereby driving their polarization toward the M1 phenotype.[18] We hypothesized that irradiated melanoma cells induce an M1‐like phenotype in macrophages by upregulating the expression of IRF7. Here, IL15 is linked to melanoma.