The activation of proinflammatory cells in adipose tissue leads to adipocyte death and eventual fibrosis and is a hallmark of adipose tissue dysfunction and obesity‐associated insulin resistance.[15] As shown in Figure S3B (Supporting Information), decreased fibrosis‐related genes were observed in eWAT from CREBZF MKO mice, indicating improved extracellular matrix (ECM) remodeling. Here, CREBZF is linked to obesity disorder.