In hepatocytes, CREBZF is induced by insulin and inhibits the transcription of insulin‐induced genes (Insigs), leading to increased hepatic steatosis.[8] CREBZF increases hepatic stellate cell activation and fibrosis by stimulating osteopontin in NASH.[9] Moreover, CREBZF inhibits liver regeneration by repressing STAT3.[10] Although transcriptional networks of CREBZF in liver metabolism and bZIP proteins are involved in inflammation, such as the C/EBP family, whether CREBZF regulates inflammatory pathways and insulin resistance remains unknown. Here, CREBZF is linked to metabolic dysfunction-associated steatohepatitis.