The activation of proinflammatory cells in adipose tissue leads to adipocyte death and eventual fibrosis and is a hallmark of adipose tissue dysfunction and obesity‐associated insulin resistance.[15] As shown in Figure S3B (Supporting Information), decreased fibrosis‐related genes were observed in eWAT from CREBZF MKO mice, indicating improved extracellular matrix (ECM) remodeling. This evidence concerns the gene CREBZF and Insulin resistance.