It has been shown that miR-216a can target down-regulate JAK gene, significantly inhibit STAT3 activation, reduce the overexpression of inflammatory enzyme-inducible nitric oxide synthase, matrix metalloproteinase 9, and inflammatory cytokines tumour necrosis factor α and IL-1β due to ICS, counteract neuroinflammation, reduce cerebral infarctions, and facilitate neuronal cell survival to ameliorate neurological deficits. This evidence concerns the gene MMP9 and infarction.