IGF2 and breast cancer: For the downregulated genes, we detected a strong enrichment of KEGG terms for homologous recombination, DNA repair, cell cycle, and PI3K-AKT signaling (Figure 3D), which was mainly evoked by a significant decrease in transcript levels of the Fanconi anemia complementation group I, breast cancer gene 2, cyclin 2A, and IGF2 (Figure 3F).