Although most HB cases occur sporadically, cancer predisposition syndromes such as familial adenomatous polyposis coli and Beckwith-Wiedemann syndrome have been associated with HB pathogenesis,2, 3 being linked either with germline mutation of the adenomatous polyposis coli gene or epimutations at the IGF2 locus. Here, APC is linked to hemoglobin measurement.