Compared to C. sinensis (-) HCC patients, C. sinensis (+) HCC patients exhibited advanced Barcelona Clinic Liver Cancer (BCLC) stage, higher male prevalence and more liver cirrhosis as well as elevated alpha-fetoprotein (AFP), carbohydrate antigen 19–9 (CA19-9), eosinophil, complement 3 (C3), and complement 4 (C4) values. The gene discussed is C4A; the disease is cirrhosis of liver.