CENPs expression is elevated in GBM tissues and correlatedwith unfavorable overall survival in glioma patients.53 Before evaluating the effect of dual inhibitor 7, a study to assess the expression levels of CENPs was carried outand the upregulated expression of CENPE and CENPI was evidenced inTMZ-resistant GBM cells (Pt3R) compared to patient-derived GBM cells,Pt3 (Figure 8A). This evidence concerns the gene ZNF135 and central nervous system cancer.