As shown in Figure 11, Compound 7 (20 mg/kg) significantly decreased the growth of Pt#3-R-inducedtumor (Figure 11A,B);however, tazemetostat (TAZ) failed to suppress tumorgrowth (Figure 11A,B).Notably, the combination of TAZ with STA suppressed tumor growth (Figure 11A,B), experimental mice that received the cocktail(TAZ and STA) died earlier due to the systemic toxicity(Figure 11B,C). The gene discussed is F2; the disease is neoplasm.