As shown in Tables 3–5, HSP family proteins, includingHSPA1A, HSPA8, HSP90AA1, HSPB1, HSPH1, and HSPA4, were significantlyincreased in response to dual inhibitor 7 treatment.This observation is aligned with the results attained with geldanamycintreatment (a well-known HSP90 inhibitor)49,50 and confirms the HSP90-suppressive activity of compound 7 in GBM cells. The gene discussed is HSPA4; the disease is glioblastoma.