Interferon regulatory factor 3 (IRF3), but not TANK-binding kinase 1 (TBK1) and IκB kinase epsilon (IKKε), is sequestered into viral inclusion bodies (IBs) upon Ebola virus (EBOV) transcription- and replication-competent virus-like particles (trVLPs) infection. This evidence concerns the gene TBK1 and infection.