Interferon regulatory factor 3 (IRF3), but not TANK-binding kinase 1 (TBK1) and IκB kinase epsilon (IKKε), is sequestered into viral inclusion bodies (IBs) upon Ebola virus (EBOV) transcription- and replication-competent virus-like particles (trVLPs) infection. The gene discussed is IKBKE; the disease is infection.