In the final cohort of 136,691 patients (median age of 55.4 years, 62% female), the AUC for autoimmune conditions was 0.71 (95% CI 0.60–0.72) for the CRP and 0.71 (95% CI 0.69–0.72) for the ESR [15]. The gene discussed is ESR1; the disease is Autoimmunity.