Other mechanisms are involved in the recruitment of TAMs in the tumor microenvironment, including chemoattractants and their receptors, such as chemokine ligand (CCL) 2/CC receptor (R)2+, CCL-2/CCR-5+, IL-1β/IL-1 receptor (R), VEGFA/VEGFR, CSF1/CSF R, tyrosine-protein kinase receptor (Tie)/angiopoitein 2 (Ang2), CCL-5, C-X-C motif chemokine ligand (CXCL) 10, CXCL-12, and complement C1q, the latter is the most potent attractant promoting M2-like TAMs recruitment [11]. This evidence concerns the gene CCL2 and neoplasm.