IDH1 and glioblastoma: Molecular characteristics can now overrule the diagnosis based on morphological characteristics, clearly illustrated in isocitrate dehydrogenase 1 and 2 (IDH1/2) and H3-wildtype diffuse gliomas where in adult patients regardless of the histology the presence of a TERT-promotor mutation, EGFR-amplification and/or a gain of chromosome 7 together with a loss of chromosome 10 (so called “+7/-10”), warrants the diagnosis of a glioblastoma, IDH wild-type (CNS WHO grade 4) [1, 3, 8–10].